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The P2X7 receptor is the only non-selective cation-channel expressed in neurons that is directly activated by extracellular ATP. Neuronal P2X7 receptors are primarily present in somatodendritic compartments, but they may also be found on the plasma membrane. In this study, we have shown that P2X7 receptors may be also present in membrane microvesicles that are released from primary cortical neurons. We found that internalized P2X7 receptors not only recycle back to the plasma membrane but also are able to sort into specific membrane vesicles, such as synaptic vesicles. The accumulation of P2X7 receptors into synaptosomes is diminished by agents that inhibit or destabilize the microtubule network but this process is independent of N-ethylmaleimide-sensitive fusion proteins (NSF). Moreover, subcellular fractionation of rat forebrain neurons revealed that internalized P2X7 receptors are found in the synaptic vesicles and associated soluble vesicles, but not in the other fractions. The presence of this intracellular pool of P2X7 receptors in synaptic vesicles is of particular interest given that these vesicles mediate neurotransmitter release and are implicated in neurodegeneration.Saturday, March 19, 2010
My Sewing Goals for The Year Ahead
Another month closer to the end of the year. I really am not too sure what to post for this month. I think it will be easier to wait until after the boys have gone to sleep and are fast asleep before posting my goals. Also, if you are one of my followers you might have noticed that my blog posts have been lacking for a while. It has to do with my laptop. It is just not stable at all, I know weird for a laptop, but it seems to leave it’s self in a permanent reboot whenever I try to make a post. I have a wireless
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- During the era of the Byronic Hero—a period of Romanticism—Greece has been in the midst of total upheaval, and the country is depleted of its resources and people. No one is left other than the mean, cunning, cowardly, and foolish.
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return new MeasureAgnosticArgument {
Argument: &arg,
Size: 11,
}, nil
}
scopedResource := arg.ErrorValueAs(
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Rise, Tarnished, and be guided by grace to brandish the power of the Elden Ring and become an Elden Lord in the Lands Between.
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Rise, Tarnished, and be guided by grace to brandish the power of the Elden Ring and become an Elden Lord in the Lands Between.
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A vast world where open fields with a variety of situations and huge dungeons with complex and three-dimensional designs are seamlessly connected. As you explore, the joy of discovering unknown and overwhelming threats await you, leading to a high sense of accomplishment.
• Create your Own Character
In addition to customizing the appearance of your character, you can freely combine the weapons, armor, and magic that you equip. You can develop your character according to your play style, such as increasing your muscle strength to become a strong warrior, or mastering magic.
• An Epic Drama Born from a Myth
A multilayered story told in fragments. An epic drama in which the various thoughts of the characters intersect in the Lands Between.
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Ask HN: Are there any prospects for a calendar type app for mobile devices? – kxxc
I am looking for a somewhat more ambitious project than just a list of reminders. It should include live updates and allow fairly detailed access to the event, but also allow the quick publication of a list of reminders for the day and the week. It should allow an automatic year view, e.g. year view with a day view in the bottom left (like Google Calendar).
======
andrewdschubert
Look at Moment, it has a native mobile app for Android/iOS that’s quite
interesting, a bit different from the other calendar apps. Here’s an article I
wrote about it: [
moment-a…](
mobile-calendar-for-ios)
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