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In the absence of Unc-51, many glutamate receptor clusters are not associated with Bruchpilot, and ultrastructural analysis shows which is smaller than the active zones. We show that some of these receptors are associated with L-glutam but not with other glutamates, indicating that they are mainly L-glutamate sensitive.
This is consistent with our observation that more complex forms of L-glutamate, such as L-glutamine, can react with endogenous L-glutamates, and therefore with Bruchpilot.
As a side note, we describe the structure of a receptor that can be associated with Bruchpilot, but not with L-Glutamate. https://sharingourwealth.com/social/upload/files/2022/06/SwZmAuTtUl6hGtcZCdPL_07_8fbb0b28d006e6607843ec597eccfc02_file.pdf
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